A Review on Phytochemical and Pharmacological Study of Herbal Medicinal Plant: Abrus precatorious


  • Samiksha Dafar Nagpur College of Pharmacy, Wanadongri, Nagpur, Maharashtra, 441110
  • Bhelke M. R. Nagpur College of Pharmacy, Wanadongri, Nagpur, Maharashtra, 441110
  • Nashine. A. M. Nagpur college of Pharmacy, Hingna Rd, Wanadongri, Nagpur, Maharashtra.
  • Dafar D. P. Nagpur College of Pharmacy, Wanadongri, Nagpur, Maharashtra, 441110
  • Rathod S. S. Nagpur College of Pharmacy, Wanadongri, Nagpur, Maharashtra, 441110




Herbal plants are those whose aromatic, medicinal, or nutritional qualities are highly valued. They have been utilized for innumerable years in conventional medicine and continue to be utilized as a natural alternative to conventional medicine. An extensive variety of herbal plants exist, each possessing distinct advantages. It is imperative to acknowledge that although herbal plants are generally regarded as secure, they may cause adverse effects or interactions with specific medications in some individuals. Be sure to seek the advice of a healthcare professional prior to utilizing herbal remedies. Abrus precatorious, possesses pharmacological properties that make it a promising candidate for the development of novel drugs, according to scientific research. Studies have shown, for instance, that extracts derived from the plant possess antibacterial, antitumor, and antidiabetic properties. A prevalent constituent of numerous tropical and subtropical ecosystems, especially in regions characterized by disturbed or degraded soils, is Abrus precatorius. It thrives in moist tropical forests and arid scrublands alike, and is renowned for its prolific development and ability to displace indigenous species. Abrus precatorius is therefore classified as an invasive species in numerous countries, such as Australia, Hawaii, and Florida. Nevertheless, due to its propensity for misuse, elevated toxicity, and invasive characteristics, this plant necessitates cautious handling and management. Pharmacological activities, chemical constituents, phytochemical analysis, and analytical techniques were the primary focuses of the present study.


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How to Cite

Dafar, S., M. R., B., A. M., N., D. P., D., & S. S., R. (2023). A Review on Phytochemical and Pharmacological Study of Herbal Medicinal Plant: <i>Abrus precatorious</i>. International Journal of Newgen Research in Pharmacy & Healthcare, 1(2), 161–173. https://doi.org/10.61554/ijnrph.v1i2.2023.31





Khairullah AR, Solikhah TI, Ansori ANM, Hanisia RH, Puspitarani GA, Fadholly A, et al. Medicinal importance of Kaempferia galanga L. (Zingiberaceae): A comprehensive review. J Herbmed Pharmacol. 2021; 10(3):281-8. http://herbmedpharmacol.com/Article/jhp-37998 DOI: https://doi.org/10.34172/jhp.2021.32

Das A, Jain V, Mishra A. A brief review on a traditional herb: Abrus precatorius (L.). Int J Forensic Med Toxicol Sci. 2016; 1(1):1-10 DOI: https://doi.org/10.18231/j.ijfmts.2016.001

Janghel V, Patel P, Chandel SS. Plants used for the treatment of icterus (jaundice) in Central India: A review. Ann Hepatol. 2019; 18(5):658-72. https://doi.org/10.1016/j.aohep.2019.05.003 DOI: https://doi.org/10.1016/j.aohep.2019.05.003

Kuo S-C, Chen S-C, Chen L-H, Wu J-B, Wang J-P, Teng C-M. Potent antiplatelet, antiinflammatory, and antiallergic isoflavanquinones from the roots of Abrus precatorius. Planta Med. 1995; 61(04):307-12. DOI: https://doi.org/10.1055/s-2006-958089

Mølgaard P, Nielsen SB, Rasmussen DE, Drummond RB, Makaza N, Andreassen J. Anthelmintic screening of Zimbabwean plants traditionally https://doi.org/10.1016/S0378- 8741(00)00377-9

Jouad H, Haloui M, Rhiouani H, El Hilaly J, Eddouks M. Ethnobotanical survey of medicinal plants used for the treatment of diabetes, cardiac and renal diseases in the North centre region of Morocco (Fez- Boulemane). J Ethnopharmacol. 2001; 77(2- 3):175-82. https://doi.org/10.1016/S0378-8741(01)00289-6 DOI: https://doi.org/10.1016/S0378-8741(01)00289-6

Lalithakumari H, Reddy V V, Rao GR, Sirsi M. Purification of Proteins from Abrus precatorius L. & Their Biological Properties. Indian J Biochem. 1971; 8(4):321-3.

Tabasum S, Khare S, Jain K. Spectrophotometric quantification of total phenolic, flavonoid, and alkaloid contents of Abrus precatorius L. seeds. Asian J Pharm Clin Res. 2016; 9(2):3714.

Solikhah TI, Solikhah GP. Effect of Muntingia calabura L. leaf extract on blood glucose levels and body weight of alloxaninduced diabetic mice. Pharmacogn J. 2021; 13(6):1450-5. https://doi.org/10.5530/pj.2021.13.184 DOI: https://doi.org/10.5530/pj.2021.13.184

Prabha M, Perumal C, Kumar P, Soundarrajan, Srinivasan S SR. Review Article Pharmacological activities of Abrus precatorius (L.) seeds. Int J Pharm Med Res J homepage. 2015; 3(2):195- 200.

Verma D, Tiwari SS, Srivastava S, Rawat AKS. Pharmacognostical evaluation and phytochemical standardization of Abrus precatorius L. seeds. Nat Prod Sci. 2011; 17(1):51-7.

Polito L, Bortolotti M, Maiello S, Battelli MG, Bolognesi A. Plants producing ribosomeinactivating proteins in traditional medicine. Molecules. 2016; 21(11):1560. https://doi.org/10.3390/molecules21111560 DOI: https://doi.org/10.3390/molecules21111560

Elisabetsky E, Figueiredo W, Oliveria G. Traditional Amazonian nerve tonics as antidepressant agent: Chaunochiton kappleri: A case study. J Herbs Spices Med Plants. 1992; 1(1-2):125-62. DOI: https://doi.org/10.1300/J044v01n01_11

Wambebe C, Amosun SL. Some neuromuscular effects of the crude extracts of the leaves of Abrus precatorius. J Ethnopharmacol. 1984; 11(1):49-58. https://doi.org/10.1016/0378-8741(84)90095-3 DOI: https://doi.org/10.1016/0378-8741(84)90095-3

Ibrahim AM. Anthelmintic activity of some Sudanese medicinal plants. Phyther Res. 1992;6(3):155-7. https://doi.org/10.1002/ptr.2650060312 DOI: https://doi.org/10.1002/ptr.2650060312

Alhamdani M, Brown B NP. Abrin poisoning in an 18-month-old child. Am J Case Rep. 2015; 16:146-8. https://doi.org/10.12659/AJCR.892917

Khairullah AR, Solikhah TI, Ansori ANM, Hidayatullah AR, Hartadi EB, Ramandinianto SC, et al. Review on the Pharmacological and Health Aspects of Apium Graveolens or Celery: An Update. Syst Rev Pharm. 2021; 12(1):606-12

Okhale SE, EM N. Abrus precatorius Linn (Fabaceae): phytochemistry, ethnomedicinal uses, ethnopharmacology and pharmacological activities. Int J Pharm Sci Res. 2016; 1:37-43.

Verma S. Phytochemical and pharmacological study on Abrus precatorius. Asian J Plant Sci Res. 2016; 6(2):24-6.

Bhakta S, Awal A, Das SK. Herbal contraceptive effect ofAbrus precatorius, Ricinus communis, and Syzygium aromaticum on anatomy of the testis of male Swiss albino mice. J Adv Biotechnol Exp Ther. 2019; 2(2):36-43. https://doi.org/10.5455/jabet.2019.d23

Nath D, Sethi N, Singh RK, Jain AK. Commonly used Indian abortifacient plants with special reference to their teratologic effects in rats. J Ethnopharmacol. 1992; 36(2):147-54. https://doi.org/10.1016/0378-8741(92)90015-J

Tripathi S, Maiti TK. Immunomodulatory role of native and heat denatured agglutinin fromAbrus precatorius. Int J Biochem Cell Biol. 2005; 37(2):451-62. https://doi.org/10.1016/j.biocel.2004.07.015 DOI: https://doi.org/10.1016/j.biocel.2004.07.015

Choudhari AB, Sayyed N, Khairnar AS. Evaluation of antiserotonergic activity of ethyl acetate extract ofAbrus precatorius leaves. J Plant Res. 2011; 4(3):570-2

Patil MM, Patil SV, Akki AS, Lakhkar B BS. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin diagnostic Res JCDR. 2016; 10(3):SD03-4. https://doi.org/10.7860/JCDR/2016/18234.743 9 DOI: https://doi.org/10.7860/JCDR/2016/18234.7439

Acharya D, Sancheti G, Shrivastava A. Medicinal plants for curing common ailments in India Positive Health. 2004; 102: 28-30. 26. Adesina SK. Studies on some plants used as anticonvulsants in Amerindian and African traditional medicine. Fitoterapia 1982; 53:147–162.

Chopra RN. Indigenous drugs of India their medical and economic aspects, the art press, Calcutta, India. 1933; 550.

Premanand R & Ganesh T. Neuroprotective effects ofAbrus precatorius Linn. Aerial extract on hypoxic neurotoxicity induced rats. Intern J Chem and Pharmac Sci. 2010; 1(1).

Desai VB, M Sirsi. Antimicrobial activity of Abrus precatorius. Ind J Pharm. 1966; 28: 164.

Panneerselvam K, SC lin, CL Liu, YC Liaw, JY Lin, TH Lu. Crystallization of agglutinin from the seeds of Abrus precatorius. Acta Crystallographic a Section D Biological Crystallography. 2000; 56(7): 898–899 DOI: https://doi.org/10.1107/S0907444900005047

Desai VB, M Sirsi, M Shankarappa, AR Kasturibai. Studies on the toxicity ofAbrus precatorius effect of aqueous extracts of seeds on mitosis and meiosis in grasshopper, (Poecilocera picta). Indian J Exp Biol. 1966; 4: 164.

Bhaduri B, CR Ghose, AN Bose, BK Moza, UP Basu. Anti-fertility Activity of some medicinal Plants. Indian J Exp Biol. 1968; 6: 252-253

Nath D, N Sethi, RK Singh, AK Jain. Commonly used Indian abortifacient plants with special reference to their teratologic effects in rats. J Ethnopharmacol 1992; 36(2): 147–154. DOI: https://doi.org/10.1016/0378-8741(92)90015-J

Carbajal D, A Casaco, L Arruzazabala, R Gonzalez, V Fuentes. Pharmacological screening of plant decoctions commonly used in Cuban folk medicine. J Ethnopharmacol. 1991; 33(1/2): 21–24. DOI: https://doi.org/10.1016/0378-8741(91)90155-7

Nwodo OFC, JH Botting. Uterotonic activity of extracts of the seeds of Abrus precatorius. Planta Med. 1983; 47(4): 230–233. 36. Gogte VM. Ayurvedic Pharmacology and therapeutic uses of medicinal plants (Dravyagunavignyam). India: Bharatiya Vidya Bhavan; 2000, p. 600-601. DOI: https://doi.org/10.1055/s-2007-969994

Chang HM, Chiang TC, Mak TCW. Isolation and structure elucidation of abruslactone A: a new oleanene-type triterpene from the roots and vines ofAbrus precatorius L. J Chem Soc Chem Commun 1982; (20): 1197-1198 DOI: https://doi.org/10.1039/c39820001197

Choi YH, Kinghorn AD, Shi XB, Zhang H, Teo BK. Abrusoside A: a new type of highly sweet triterpene glycoside. J Chem Soc Chem Commun 1989; (13): 887-888. DOI: https://doi.org/10.1039/c39890000887

Kennelly EJ, Cai L, Kim NC, Kinghorn AD. Abrusoside e, a further sweet-tasting cycloartane glycoside from the leaves of Abrus precatorius. Phytochemistry 1996; 41(5): 1381-1383. DOI: https://doi.org/10.1016/0031-9422(95)00792-X

Bhaumik HL. Hydrocarbons, fatty acids, triterpenoid and sterols in the seeds of Abrus precatorius. Sci Cult 1987; 53(1): 23-24.

Anderson JD, Mandava N, Gunn CR. Plant growth inhibitor from Abrus precatorius seeds. Plant Physiol 1972; 49: 1024-1026. DOI: https://doi.org/10.1104/pp.49.6.1024

Krishnamoorthy V, Seshadri TR. Survey of anthocyanins from Indian sources: Part lll. J Sci Ind Res 1962; 21: 591-593.

Ae L, Bnrl J, Nf N. Protective effect ofAbrus precatorius seed extract following alcohol induced renal damage. Eur J Sci Res 2009; 25(3): 428-436.

Sudaroli M and Chatterjee TK. Evaluation of red and white seed extracts of Abrus precatoriusLinn. against freund’s complete adjuvant induced arthritis in rats. J Med Plants Res 2007; 1(4): 86-94. DOI: https://doi.org/10.1007/978-0-387-70638-2_5

Sinha R. Post-testicular antifertility effects of Abrus precatorius seed extract in albino rats. J Ethnopharmacol 1990; 28(2): 173-181.

Subbaiah MV, Yuvaraja G, Vijaya Y, Krishnaiah A. Equilibrium, kinetic and thermodynamic studies on biosorption of Cu (II), Cd (II), P b(II) and Ni (II) from aqueous solution by chitosan Abrus precatoriusblended beads. J Chem Pharm Res 2011; 3(2): 365-378.

Karpurashetti NB, Hiremath SK, Manjulabai KH KS. A review of gunja (Abrus precatorius. linn) on both aspect of medicine as well as poison. Asian J Pharm Res Dev. 2014; 2(1):66-7.

Alhamdani M, Brown B NP. Abrin poisoning in an 18-month-old child. Am J Case Rep. 2015; 16:146-8. https://doi.org/10.12659/AJCR.892917 DOI: https://doi.org/10.12659/AJCR.892917

Saganuwan SA, Onyeyili PA. Biochemical effects of aqueous leaf extract of Abrus precatorius (Jecquirity bean) in Swissalbino mice. Herba Rolonica, 2010; 56(3): 63-80.

Atuboyedia WO, Jonah SA, Chinagoro TOE. Antifertility effects of aqueous extract of Ocimum gratissimum L. leaves in male mice. Journal of Medicial plants Research, 2010; 4(9): 809-816.

Bhakta S, Awal A, Das SK. Herbal contraceptive effect of Abrus precatorius, Ricinus communis, and Syzygium aromaticum on anatomy of the testis of male Swiss albino mice. J Adv Biotechnol Exp Ther., 2019; 2(2): 36-43. DOI: https://doi.org/10.5455/jabet.2019.d23

Bhatt N, Chawla SL, Rao MV 2007. Contraceptive evaluation of seed extract of Abrus. Journal of herbal medicine and toxicology, 2001; 1(1): 47-50.

Sinha R. Post-testicular antifertility effects of Abrus precatorius seed extract in albino rats. Journal of Ethnopharmacology, 1990; 28(2): 173-81. 3 DOI: https://doi.org/10.1016/0378-8741(90)90027-Q

Rao MV. Antifertility effects of alcoholic seed extract ofAbrus precatorius Linn. in male albino rats. Acta Euopaear Fertliitica, 1987; 8(3): 217-20. DOI: https://doi.org/10.1016/0378-8741(88)90044-X

Sinha S, Mathur RS. Effect of steroidal fraction of seeds ofAbrus precatorius Linn. on rat testis. Indian Journal Experimental Biology, 1990; 28(8): 752-6.

Jahan S, Rasool S, Khan MA, Ahmad M, Zafar M, Arsahd M, Abbasi AM. Antifertiltity effect of ethanolic seed extract of Abrus precatorius L on sperm production and DNA integrity in adult male mice. Journal of Medical Plants Research, 2009; 3(10): 809-814

Ojewole JA. Laboratory evaluation of the hypoglycemic effect of Anacardium occidentale Linn (Anacardiaceae) stem-bark extracts in rats, Experimental Clinical Pharmacol, 2003; 25: 199–204 DOI: https://doi.org/10.1358/mf.2003.25.3.769640